Collagenase clostridium histolyticum
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144 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dupuytren contracture | D004387 | EFO_0004229 | M72.0 | 1 | 2 | 13 | 9 | 13 | 38 |
| Contracture | D003286 | EFO_0003899 | M62.4 | — | 2 | 8 | 8 | 10 | 28 |
| Penile induration | D010411 | — | N48.6 | — | 2 | 5 | 6 | 5 | 18 |
| Ulcer | D014456 | MPATH_579 | — | 2 | 3 | 2 | 7 | 3 | 16 |
| Cellulite | D000071697 | — | — | 1 | 8 | 3 | 2 | 1 | 15 |
| Diabetic foot | D017719 | EFO_1001459 | — | 1 | — | — | 8 | 1 | 10 |
| Foot ulcer | D016523 | — | — | 1 | — | — | 8 | — | 9 |
| Burns | D002056 | — | T30.0 | — | 1 | — | 2 | 2 | 5 |
| Pressure ulcer | D003668 | — | L89 | — | — | 1 | 2 | 1 | 4 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | 1 | 3 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Edema | D004487 | — | R60.9 | 2 | 4 | 2 | — | 1 | 9 |
| Macular edema | D008269 | — | — | — | — | 1 | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | 1 | — | — | 1 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | 1 | — | — | 1 |
| Skin ulcer | D012883 | — | L98.4 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bursitis | D002062 | EFO_1000941 | M71.9 | — | 4 | — | — | — | 4 |
| Varicose ulcer | D014647 | — | — | — | 2 | — | — | 1 | 3 |
| Keloid | D007627 | EFO_0004212 | L91.0 | — | 2 | — | — | — | 2 |
| Cutis laxa | D003483 | — | Q82.8 | — | 1 | — | — | 1 | 2 |
| Leg ulcer | D007871 | — | — | — | 2 | — | — | — | 2 |
| Lipoma | D008067 | — | D17.9 | — | 2 | — | — | — | 2 |
| Abdominal aortic aneurysm | D017544 | EFO_0004214 | — | — | 1 | — | — | — | 1 |
| Aneurysm | D000783 | — | I72.9 | — | 1 | — | — | — | 1 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | — | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | — | 1 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | — | — | — | — | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | — | — | — | — | 1 |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | 1 | — | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | 1 | — | — | — | — | 1 |
| Idiopathic pulmonary fibrosis | D054990 | — | J84.112 | 1 | — | — | — | — | 1 |
| Pulmonary fibrosis | D011658 | — | J84.10 | 1 | — | — | — | — | 1 |
| Interstitial lung diseases | D017563 | EFO_0004244 | J84.9 | 1 | — | — | — | — | 1 |
| Pulmonary alveolar proteinosis | D011649 | — | J84.01 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | — | — | — | — | 2 | 2 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 1 | 1 |
| Spontaneous abortion | D000022 | EFO_1001255 | O00.1 | — | — | — | — | 1 | 1 |
| Wound healing | D014945 | GO_0042060 | — | — | — | — | — | 1 | 1 |
| Vitiligo | D014820 | EFO_0004208 | L80 | — | — | — | — | 1 | 1 |
| Facial injuries | D005151 | — | S09.93 | — | — | — | — | 1 | 1 |
| Necrosis | D009336 | — | — | — | — | — | — | 1 | 1 |
| Hereditary corneal dystrophies | D003317 | — | H18.5 | — | — | — | — | 1 | 1 |
| Hernia | D006547 | — | K40-K46 | — | — | — | — | 1 | 1 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Collagenase clostridium histolyticum
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Safety
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7,310 adverse events reported
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